System Biological Determination of the Epigenomic Structure – Function Relation

– EpiGenSys –

Active RNA polymerases are fixed in
    factories.Work package 3:

Transcriptional structure relationship

In WP3 "transcriptional structure relationship" we will focus on the determination of transcription rates of selected loci by qRT-PCR, DNA and RNA FISH using intronic probes and high-resolution laser-scanning and single molecule imaging with advanced image analysis tools. Transcription-dependent changes of active and inactive loci as well as rapid synchronous transcription alteration against the unchanged background is one main interest here. These results will be compared with the global cartography of functional transcription dependencies.


  • P. Cook
  • T.A. Knoch/F. Grosveld
  • G. Längst