System Biological Determination of the Epigenomic Structure – Function Relation

– EpiGenSys –

WP2 imageWork package 2:

Intra/inter chromosomal architecture

In WP2 we will monitor intra/inter chromosomal contacts and architecture using a novel combination of chromosome conformation capture technology and high-throughput deep sequencing. This will result in absolute DNA-DNA interaction probability maps for individual loci in their global nuclear context. From these we will derive 3D conformations of the chromatin fiber and its higher-order architecture, i.e. its folding into loops and loop clusters, using algorithms recently developed by us.


Participants

  • T.A. Knoch/F. Grosveld
  • P. Cook
  • K. Rippe
  • G. Längst