System Biological Determination of the Epigenomic Structure – Function Relation

– EpiGenSys –

WP1 SchemeWork package 1:

Nucleosomal association changes

In WP1 changes in nucleosomal association in relation to the DNA sequence and the activity of ATP-driven chromatin remodelling complexes will be compared by determination of nucleosome positions using high-throughput sequencing. The resulting nucleosomal localization probability maps will be evaluated by a novel combination of analysis tools and innovative generic data ontologies. The relation to epigenetic modifications, to the activity of ATP-driven remodelling complexes and the compaction degree of the chromatin fiber to understand chromatin morphogenesis and fiber formation.


Participants

  • G. Längst
  • K. Rippe
  • G. Wedemann
  • T.A. Knoch/F. Grosveld